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Antibody levels to Bordetella pertussis in 10‐yr‐old children with atopy and atopic asthma
Author(s) -
BlancoQuiros Alfredo,
GarciaMarcos Luis,
Garrote Jose A.,
MartinezTorres Antonia E.,
Leon Alberto
Publication year - 2005
Publication title -
pediatric allergy and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.269
H-Index - 89
eISSN - 1399-3038
pISSN - 0905-6157
DOI - 10.1111/j.1399-3038.2005.00331.x
Subject(s) - atopy , medicine , bordetella pertussis , immunology , asthma , immunoglobulin e , antibody , pertussis vaccine , vaccination , allergy , whooping cough , immunization , biology , bacteria , genetics
Suboptimal immune responses to vaccination have been suggested among atopic infants. The aim of this study was to assess the influence of atopy and atopic asthma on the humoral response to Bordetella pertussis vaccination. Immunoglobulin (Ig)G and IgA specific antibodies were measured by enzyme linked‐immunosorbent assay in 102, 10‐yr‐old atopic children (66 of them also being asthmatics) and compared with 76 non‐atopic and 53 non‐atopic non‐asthmatic controls of similar age. The levels of antibodies and the percentage of positives to B. pertussis were comparable in all groups. Children with a very high total serum immunoglobulin (Ig)E (Percentile (Pct) > 90th) showed higher (p = 0.01) IgG pertussis antibodies than children with very low serum IgE (Pct < 10th). In conclusion, we found normal pertussis antibody levels in atopic and in atopic asthmatic children in late childhood, thus overriding any possible suboptimal response during infancy.