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Effect of BCG vaccination in asthmatic schoolchildren
Author(s) -
Vargas Mario H.,
BernalAlcántara Demetrio A.,
Vaca Miguel A.,
FrancoMarina Francisco,
Lascurain Ricardo
Publication year - 2004
Publication title -
pediatric allergy and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.269
H-Index - 89
eISSN - 1399-3038
pISSN - 0905-6157
DOI - 10.1111/j.1399-3038.2004.00198.x
Subject(s) - medicine , vaccination , asthma , immunology , placebo , bcg vaccine , peripheral blood mononuclear cell , gastroenterology , pathology , biochemistry , chemistry , alternative medicine , in vitro
Recent studies have explored the effect of Bacilli Calmette‐Guerin (BCG) or Mycobacterium vaccae vaccination in asthmatic patients, yielding conflicting results. We investigated the effect of BCG vaccination in asthmatic schoolchildren, especially focusing on the cytokine pattern released by mononuclear cells. After a 1‐yr run‐in period, 67 asthmatic schoolchildren received intradermal immunization with BCG (33 patients) or placebo (34 patients). Both groups were followed during 1 yr. Serum immunoglobulin E (IgE) levels did not change after BCG (407.1 ± 86.6 vs. 415.1 ± 86.7 IU/ml, mean ± s.e.m.), but increased after placebo (406.7 ± 67.0 vs. 619.7 ± 90.7 IU/ml, p = 0.001) administration. Interleukin (IL)‐4 and interferon (IFN)‐ γ measured in the supernatant of stimulated cultured blood mononuclear cells did not change in the BCG group (10.8 ± 2.3 vs. 17.9 ± 5.7 pg/ml, and 348.6 ± 118.0 vs. 354.8 ± 139.0 pg/ml, respectively), while in the control group IL‐4 increased (from 6.7 ± 1.3 to 16.1 ± 6.0 pg/ml, p < 0.05), and IFN‐ γ decreased (from 279.9 ± 82.1 to 232.1 ± 109.6 pg/ml, p = 0.01). In comparison with their initial status, most patients maintained the same asthma severity and the same proportion of emergency room visits at the end of the study. The proportion of those in whom asthma improved or worsened was the same in both groups. We concluded that, contrary to the common hypothesis, BCG vaccination in asthmatic children was unable to cause a long‐term reinforcement of Th 1 response, although it could avoid the increased Th 2 response observed in control patients.