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Recurrent parotitis in selective IgA deficiency
Author(s) -
Shkalim Vered,
Monselise Yehudit,
Mosseri Ronen,
Finkelstein Yaron,
Garty Ben Zion
Publication year - 2004
Publication title -
pediatric allergy and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.269
H-Index - 89
eISSN - 1399-3038
pISSN - 0905-6157
DOI - 10.1111/j.1399-3038.2004.00163.x
Subject(s) - parotitis , medicine , immunology , saliva , etiology , selective iga deficiency , antibody , immunoglobulin a , pathogenesis , immunodeficiency , disease , immunoglobulin g , immune system , dentistry
Recurrent parotitis is an uncommon condition in children. In most cases the etiology is unknown, although the disease is occasionally associated with viral infections, autoimmune disorders and immunodeficiency. We describe, for the first time, a child with recurrent parotitis and isolated immunoglobulin A (IgA) deficiency, without autoimmune disease. As IgA is the main immunoglobulin secreted into the mucosal surfaces, including that of the respiratory and gastrointestinal tracts, and into the saliva, the lack of IgA may be involved in the pathogenesis of recurrent parotitis. We recommend that IgA and other immunoglobulins be tested in all cases of recurrent parotitis.