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Reduced plasma c‐AMP levels in children with atopic dermatitis
Author(s) -
Salpietro Damiano Carmelo,
Naccari Francesco,
Polimeni Lsabella,
Pellegrino Cristina
Publication year - 1998
Publication title -
pediatric allergy and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.269
H-Index - 89
eISSN - 1399-3038
pISSN - 0905-6157
DOI - 10.1111/j.1399-3038.1998.tb00358.x
Subject(s) - medicine , atopic dermatitis , immunoglobulin e , pathophysiology , plasma levels , immunology , allergy , endocrinology , antibody
Plasma levels of cAMP and serum concentrations of IgE have been determined in children with acute atopic dermatitis (AD) and in a healthy control group, to illuminate the pathophysiological mechanisms that cause AD. There were significantly lower plasma levels of cAMP (P < 0,001) and significantly higher levels of serum IgE (P < 0.004) in children with AD, in comparison with a healthy control group. It is possible that defective control of c‐AMP levels could contribute to the immunopathogenesis of AD and monitoring levels may be of value in the clinical evaluation of the disease.