Premium
Do parental smoking and history of allergy influence cord‐serum IgE?
Author(s) -
Atict A.,
Altintas D.,
Yiiksel B.,
Evliyaog̀lu N.,
Evrüke C.,
Satar M.,
Güneşer S.
Publication year - 1995
Publication title -
pediatric allergy and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.269
H-Index - 89
eISSN - 1399-3038
pISSN - 0905-6157
DOI - 10.1111/j.1399-3038.1995.tb00288.x
Subject(s) - medicine , family history , allergy , pregnancy , pediatrics , immunoglobulin e , cord blood , smoking history , passive smoking , obstetrics , immunology , antibody , genetics , environmental health , biology
The associations between parental smoking habits during pregnancy, family history of allergy, and IgE levels in cord‐serum IgE (clgE) were investigated prospectively in 1251 infants. Mean clgE levels were similar in infants with positive and negative family history of allergy (0.50 and 0.54 kU/1, respectively). In infants with a positive family history of allergy whose mothers smoked more than 10 cigarettes a day, however, the mean clgE level was significantly higher (0.78 kU/1) than that in infants of nonsmoking mothers (p = 0.011). Similarly, the mean clgE level was significantly higher in boys (0.61 kU/1) than in girls (0.51 kU/1) of nonsmoking parents (p = 0.03). However, in infants of smoking parents, there was no significant difference in the mean clgE level between boys and girls. A total of 178 (14%) mothers and 477 (38%) fathers were current smokers, and in 128 (10%) cases, both parents were active smokers. The mean clgE level tended to be slightly higher in infants of smoking mothers, especially when the mother consumed more than 10 cigarettes a day (0.63 vs 0.54 kU/1) (p > 0.05). Thus, clgE levels were higher only in genetically prone babies whose mothers consumed more than 10 cigarettes a day.