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Changes in the concentration and distribution of immunoglobulin‐producing cells in SIDS palatine tonsils
Author(s) -
Stoltenberg L.,
Vege Å.,
Saugstad O. D.,
Rognum T. O.
Publication year - 1995
Publication title -
pediatric allergy and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.269
H-Index - 89
eISSN - 1399-3038
pISSN - 0905-6157
DOI - 10.1111/j.1399-3038.1995.tb00258.x
Subject(s) - immunoglobulin d , medicine , germinal center , sudden infant death syndrome , lymph , pathology , antibody , reticular connective tissue , immunology , b cell , pediatrics
Seventeen sudden infant death syndrome (SIDS) cases and 9 controls, were examined immunohistochemically with regard to the presence of IgA‐, IgM‐, IgD, and IgG, as well as for thesubtypes IgG 1 , IgG 2 ‐, IgG 3 ‐, and IgG 4 ‐immunocytes. Differences in compartmentalization were also investigated. Differences were demonstrated between SIDS and controls in total number of IgG cells per 0.1 mm 2 tissue area (median: 18.3, range: 12.3‐30.2 versus median: 6.3, range: 2.0‐14.6) (p<0.01), and for IgA immunocytes (median: 3.9, range: 2.4‐5.0 versus median: 1.5, range: 1.1‐3.7) (p<0.05), while no differences were demonstrated for IgM cells (median: 1.8, range: 1.2‐3.3 versus median: 1.8, range: 0.7‐5.6) or IgD cells (median: 1.9, range: 0.8‐2.9 versus median: 1.6, range: 0.7‐2.4). Differences were demonstrated between SIDS and control IgG plasma cells in all the four palatine tonsillar compartments; germinal centre (p<0.01), mantle zone (p<0.05), interfollicular area (p<0.01) and reticular epithelium (p<0.01). Furthermore, the number of IgA cells was higher in SIDS vs. controls in both the germinal centre (median: 1.4, range: 0.6‐2.1 versus median: 0.6, range: 0.3‐1.3) (p<0.05) and in the interfollicular area (median: 2.2, range: 1.1‐3.1 versus median: 0.5, range: 0.4‐2.0) (p<0.01). For IgM immunocytes, differences were demonstrated in the germinal centre (median: 1.0, range: 0.4‐1.6 versus median: 0.4, range: 0.3‐1.3) (p<0.01) as well as in the germinal centre (median: 0.6, range: 0.5‐0.8 versus median: 0.4, range: 0.3‐0.7) (p<0.01) and in the interfollicular area (median: 1.2, range: 0.8‐1.6 versus median: 0.5, range: 0.5‐0.7) (p<0.01) in the IgD immunocyte group. The total number of IgG 1 ‐ and IgG 3 ‐immunocytes were increased in SIDS (median 15.6, range: 5.3‐58.9 versus median: 2.5, range: 1.5‐8.4) (p<0.01) and (median: 3.6, range: 0.4‐8.6 versus median: 1.1, range: 0.4‐1.3) (p<0.01) respectively. Furthermore, significantly increased numbers of these two subclasses, were seen in all the four compartments in the SIDS cases. The palatine tonsillar immune system is stimulated in SIDS. Furthermore, the changes being predominantly in the germinal centres and interfollicular areas, are indicating a recent stimulation, and the IgG‐subgroup response pattern makes a viral protein antigen the most likely stimulant.;