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Detection of GM‐CSF in the sera of children with Langerhans’ cell histiocytosis
Author(s) -
Emile J.F.,
Tartour E.,
Brugières L.,
Donadieu J.,
Deist F. Le,
Charnoz I.,
Fischer A.,
Fridman W.H.,
Brousse N.
Publication year - 1994
Publication title -
pediatric allergy and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.269
H-Index - 89
eISSN - 1399-3038
pISSN - 0905-6157
DOI - 10.1111/j.1399-3038.1994.tb00232.x
Subject(s) - langerhans cell histiocytosis , medicine , langerhans cell , histiocytosis , immunology , pathology , in vitro , microbiology and biotechnology , antigen , biology , biochemistry , disease
GM‐CSF induces proliferation and activation of Langerhans’ cells in vitro. The density of Langerhans’ cells in human tumours is correlated to the in situ density of GM‐CSF, and intradermal injection of GM‐CSF induces local accumulation of Langerhans’ cells. Therefore, we investigated the presence of GM‐CSF in the sera of children with Langerhans’ cell histiocytosis (LCH). We detected GM‐CSF in the sera of all children with disseminated and active LCH, but not in the sera of patients with localized (i.e. bone) LCH. These results suggest that GM‐CSF level is related to extent and the activity of LCH.