Premium
Chronic meningococcemia in a child with a deficiency of the sixth component of complement
Author(s) -
Fasano M. B.,
Sullivan K.,
Ibsen L.,
Winkelstein J. A.
Publication year - 1993
Publication title -
pediatric allergy and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.269
H-Index - 89
eISSN - 1399-3038
pISSN - 0905-6157
DOI - 10.1111/j.1399-3038.1993.tb00094.x
Subject(s) - meningococcal disease , medicine , neisseria meningitidis , immunology , disease , meningococcal infections , complement (music) , complement system , pediatrics , immune system , biology , bacteria , biochemistry , complementation , gene , phenotype , genetics
Chronic meningococcemia represents an uncommon manifestation of meningococcal disease. Microbial and host factors which may predispose to this form of meningococcal disease are not understood. Although acute meningococcal disease is frequently found in patients with terminal complement deficiencies, the relationship of chronic meningococcemia to complement deficiencies is unclear. We present a case report and a review of the literature describing chronic meningococcemia in association with deficiencies of the complement system. A total of eight cases were identified, all of whom were male. Six of the eight patients were children and two of the eight had a previous history of meningococcal disease. This case report, in conjunction with the previously reported cases, suggests an association between complement deficiencies and chronic meningococcemia.