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Responses of plasma vasoactive intestinal polypeptide to methacholine and exercise loading in children and adolescents with bronchial asthma
Author(s) -
Ohzeki T.,
Ishitani N.,
Hanaki K.,
Motozumi H.,
Ohtahara H.,
Fukushima K.,
Nakai S.,
Kishida M.,
Kobayashi S.,
Shiraki K.
Publication year - 1993
Publication title -
pediatric allergy and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.269
H-Index - 89
eISSN - 1399-3038
pISSN - 0905-6157
DOI - 10.1111/j.1399-3038.1993.tb00061.x
Subject(s) - methacholine , vasoactive intestinal peptide , medicine , asthma , inhalation , basal (medicine) , vasoactive , bronchial hyperreactivity , anesthesia , cardiology , endocrinology , gastroenterology , respiratory disease , neuropeptide , lung , receptor , insulin
Responses of plasma vasoactive intestinal polypeptide (VIP) to methacholine inhalation and to exercise loading were studied in asthmatic patients to clarity a significant role of the peptidc. The mean of basal VIP in asthmatics was not significantly different from the normals. The levels were increased after FEV (1. 0) (forced expiratory volume in a second) decreased to 80% of the baseline following methacholine inhalation and were returned to values similar to the baseline when FEV (1. 0) recovered to 100%. Thirty minutes after the exercise, mean VIP was significantly lower in patients with the lowest FEV (1. 0). These results suggest that VIPergic system contributes, at least partly, to relax constricted bronchioles in some patients with bronchial asthma.