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Serum immunoglobulin G subclasses and serum immunoglobulin A in acute bronchiolitis in infants
Author(s) -
Carlsen K. H.,
Mellbye O. J.,
Fuglerud P.,
Johansen B.,
Solheim A. B.,
Belsnes D.,
Danielsen A.,
Henrichson L.
Publication year - 1993
Publication title -
pediatric allergy and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.269
H-Index - 89
eISSN - 1399-3038
pISSN - 0905-6157
DOI - 10.1111/j.1399-3038.1993.tb00060.x
Subject(s) - bronchiolitis , medicine , bronchitis , immunology , immunoglobulin a , antibody , population , lower respiratory tract infection , respiratory system , immunoglobulin g , respiratory tract infections , pediatrics , virus , environmental health
Serum IgG subclasses and Serum IgA were studied in 43 infants with acute bronchiolitis and 20 healthy infants. IgG subclasses were determined by a capture ELISA and IgA was quantified by turbidimetry. IgG1 concentrations were significantly lower in infants with bronchiolitis than in normal infants. The other IgG subclasses and IgA did not differ between the groups. The subgroups of infants with bronchiolitis who had previously suffered from otitis media or bronchitis, had significantly lower IgG2 than the other infants with bronchiolitis. The same was found for infants with bronchiolitis who had suffered from three or more lower respiratory tract infections. In infants who had suffered from upper or lower respiratory infections before the acute bronchiolitis, IgA was significantly higher than in infants without previous respiratory infections. Ten infants with bronchiolitis (23%) had IgGl deficiency, that is values below the lower reference limit calculated in a population of healthy Norwegian infants. No healthy infants had any IgGl deficiency. No infant with bronchiolitis had IgG2 or IgG3 deficiency. The low IgGl values found in infants with acute bronchiolitis, may be one cause for infants to be more susceptible to RS virus infections.