Premium
IgE, IL4, and soluble Fc ɛ RII in the serum of atopic and nonatopic children
Author(s) -
Kim KwangMyong,
Mayumi Mitsufumi,
Mikawa Haruki
Publication year - 1992
Publication title -
pediatric allergy and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.269
H-Index - 89
eISSN - 1399-3038
pISSN - 0905-6157
DOI - 10.1111/j.1399-3038.1992.tb00020.x
Subject(s) - immunoglobulin e , medicine , immunology , interleukin 4 , atopy , allergy , antibody , cytokine
We correlated serum IgE, interleukin 4 (IL4) and soluble low affinity Fc receptor for IgE (sFc ɛ RII) in atopic and nonatopic children. Serum sFc ɛ RII was significantly higher in atopic than in nonatopic children (0‐2 yr). Serum sFc ɛ RII correlated closely with serum IgE in infants, but not in older children. To study further the characteristics of IgE synthesis in infants, we measured the serum level of IL4, which has been demonstrated to enhance the production of both IgE and sFc ɛ RII in vitro . Serum IL4 was significantly higher in atopic than in nonatopic infants, but there was no significant difference between atopic and nonatopic older children. These results suggest that IL4 plays an important role in the regulation of IgE synthesis in infants and that IgE synthesis in older children might be modulated by other factors.