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Spontaneous release of histamine from basophils in children with atopic dermatitis
Author(s) -
Boner A. L.,
Vici E. Folchi,
Carcereri L.,
Sette L.,
Bonizzato C.
Publication year - 1991
Publication title -
pediatric allergy and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.269
H-Index - 89
eISSN - 1399-3038
pISSN - 0905-6157
DOI - 10.1111/j.1399-3038.1991.tb00202.x
Subject(s) - histamine , medicine , atopic dermatitis , immunoglobulin e , immunology , basophil , food allergy , allergy , antibody , food intolerance
Spontaneous histamine release from basophils was evaluated in children with atopic dermatitis and in healthy controls. Patients were divided into 2 groups, one with specific IgE antibodies for food allergens (Group 1) and one without specific reaginic antibodies (Group 2). Group 1 showed significantly higher histamine release (median 7.25%) than Group 2 (median 4.2%) and healthy controls (median 2.05%). Histamine release was also significantly greater in Group 2 patients compared with healthy controls (p < 0.005). Group 1 was studied again after an exclusion diet which resulted in an improvement of symptoms and a significant reduction (p < 0.001) of histamine release. Children with atopic dermatitis both with and without IgE antibodies for food allergens present a degree of “basophil hyperreactivity” which decreases after an appropriate exclusion diet in children with associated food allergy.