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Natural history of IgE‐mediated food allergy in fully breast‐fed babies
Author(s) -
Cantani A.,
Ragno V.,
Businco L.
Publication year - 1991
Publication title -
pediatric allergy and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.269
H-Index - 89
eISSN - 1399-3038
pISSN - 0905-6157
DOI - 10.1111/j.1399-3038.1991.tb00195.x
Subject(s) - medicine , angioedema , immunoglobulin e , breast milk , food allergy , allergy , natural history , immunology , asthma , food allergens , antibody , pediatrics , biochemistry , chemistry
We have studied 21 babies with IgE‐mediated food allergy (FA) sensitized via breast milk. The diagnosis of IgE‐mediated FA was based on the response to elimination diet and challenge tests, and was confirmed by positive RAST and skin tests. The children exhibited immediate symptoms, such as urticaria, angioedema, and asthma. Only 5/21 children developed tolerance to the offending food at the median age of 14 years. The children who failed to develop tolerance still have high levels of IgE antibodies towards the offending food. In conclusion, the results of our long‐term follow‐up study show that the natural history of FA in children sensitized via breast milk may be less optimistic than generally reported.