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Reduced levels of IgG subclasses and IgA in young children with asthma
Author(s) -
Loh R. K. S.,
Thong Y. H.,
Harth S. C.,
Ferrante A.
Publication year - 1991
Publication title -
pediatric allergy and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.269
H-Index - 89
eISSN - 1399-3038
pISSN - 0905-6157
DOI - 10.1111/j.1399-3038.1991.tb00176.x
Subject(s) - medicine , subclass , asthma , immunoglobulin e , immunology , iga deficiency , allergy , antibody , immunoglobulin a , immunopathology , immunoglobulin g
Serum immunoglobulins including IgG subclasses were measured in 73 unselected children with asthma. The results showed that 22 (30%) had partial IgA and/or IgG 4 subclass deficiency. Clinical assessment showed that 21 children were infection‐prone, and 52 were not. Further analysis showed that infection‐prone children were significantly different from non‐infection‐prone children with regard to familial history of allergy (29% vs 60%, p = 0.015), elevated IgE (62% vs 33%, p = 0.021), IgA deficiency (38% vs 15%, p = 0.38) and IgG subclass deficiency (24% vs 4%, p = 0.018). These results suggest that there may be subgroups of children with asthma who are also immunodeficient.