Premium
IgG subclass deficiency in children with congenital heart disease
Author(s) -
Radford D. J.,
Thong Y. H.,
Beard L. J.,
Ferrante A.
Publication year - 1990
Publication title -
pediatric allergy and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.269
H-Index - 89
eISSN - 1399-3038
pISSN - 0905-6157
DOI - 10.1111/j.1399-3038.1990.tb00007.x
Subject(s) - subclass , medicine , immunodeficiency , immunology , isotype , primary immunodeficiency , heart disease , antibody , iga deficiency , immunopathology , immunoglobulin g , immune system , monoclonal antibody
This study of 66 children with congenital heart disease found 26 (39%) with IgG subclass deficiency, the majority being of the IgG 4 isotype. Conventional immunoiogical assessment (IgG, IgA, IgM, T cell) revealed 21 (32%) with immunodeficiency, while inclusion of IgG subclass assessment revealed a total of 35 (53%) of the 66 children had immuno‐deficiency. Children with conotruncal lesions appeared to be predisposed to immunodeficiency affecting T cells and IgG subclasses (especially IgG 4 ) while those with shunt and stenotic lesions had a broad spectrum of immunoglobulin deficiencies. There was significant correlation between immunodeficiency and proneness to infection in these children (p < 0.01). These results suggest that immunodeficiency is a frequent occurrence in children with congenital heart disease, and that IgG subclass measurements should be added to the diagnostic work‐up.