Open AccessAnalysis of interleukin‐23 receptor ( IL23R ) gene polymorphisms in systemic lupus erythematosus
Author(s) -
Sánchez E.,
Rueda B.,
Callejas J. L.,
Sabio J. M.,
OrtegoCenteno N.,
JimenezAlonso J.,
LópezNevot M. A.,
Martín J.
Publication year - 2007
Publication title -
tissue antigens
Language(s) - English
Resource type - Journals
eISSN - 1399-0039
pISSN - 0001-2815
DOI - 10.1111/j.1399-0039.2007.00881.x
Subject(s) - genotyping , immunology , taqman , medicine , polymerase chain reaction , allele , psoriasis , disease , autoimmune disease , gene , genotype , genetics , biology , antibody
The aim of this study was to evaluate the association between systemic lupus erythematosus (SLE) and polymorphisms in the interleukin‐23 receptor ( IL23R ) gene, which have been previously found to be associated with two autoimmune diseases: inflammatory bowel disease and psoriasis. Our study includes 224 SLE patients and 342 healthy controls. The genotyping of IL23R variants was carried out using a polymerase chain reaction system with predeveloped TaqMan allelic discrimination assays. No statistically significant differences were observed between SLE patients and healthy controls with any of the IL23R genetic variants. In addition, we did not find any significant differences when we stratified SLE patients according to their clinical and demographic features. These results suggest that IL23R polymorphisms do not appear to play an important role in the susceptibility or severity of SLE in the Spanish population.