Open AccessHLA‐D Antigen of Japanese Origin (LD‐Wa) and its Association with Vogt‐Koyanagi‐Harada Syndrome
Author(s) -
Yakura H.,
Wakisaka A.,
Aizawa M.,
Itakura K.,
Tagawa Y.,
Sugiura S.
Publication year - 1976
Publication title -
tissue antigens
Language(s) - English
Resource type - Journals
eISSN - 1399-0039
pISSN - 0001-2815
DOI - 10.1111/j.1399-0039.1976.tb00549.x
Subject(s) - human leukocyte antigen , locus (genetics) , allele , typing , biology , genetics , antigen , hla a , gene , disease , population , immunology , medicine , pathology , environmental health
One homozygous cell ‘Wa’ for HLA‐D alleles, associated with HLA‐Bw22J (Japanese specific variant of HLA‐Bw22), was found in a Japanese family. The HLA‐D antigenic specificity defined by this cell has been tentatively named LD‐Wa. Phenotype frequency of LD‐Wa in the Japanese population was 0.16 (13/81). HLA‐D typing for LD‐Wa was performed in patients with the Vogt‐Koyanagi‐Harada syndrome (Harada's disease) with which Bw22J is strongly associated (15/35, 42.9%; corrected P >0.02). LD‐Wa was present in 22 of 33 patients (66.7%; P >0.3). The association of LD‐Wa with Harada's disease was stronger than that of Bw22J, and this implies that there might be one of the disease susceptibility gene loci affecting the development of this disease more closely linked to an HLA‐D gene locus than the HLA‐B locus.