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Do kidney histology lesions predict long‐term kidney function after liver transplantation?
Author(s) -
Kamar Nassim,
Maaroufi Chakib,
GuilbeauFrugier Céline,
Servais Aude,
MeasYedid Vannary,
Tack Ivan,
Thervet Eric,
Cointault Olivier,
Esposito Laure,
Guitard Joelle,
Lavayssière Laurence,
Panterne Clarisse,
Muscari Fabrice,
Bureau Christophe,
Rostaing Lionel
Publication year - 2012
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1111/j.1399-0012.2012.01682.x
Subject(s) - medicine , kidney , renal function , urology , biopsy , immunosuppression , kidney transplantation , transplantation , calcineurin , liver transplantation , nephrology , kidney disease , gastroenterology , surgery , pathology
Histological renal lesions observed after liver transplantation are complex, multifactorial, and interrelated. The aims of this study were to determine whether kidney lesions observed at five yr after liver transplantation can predict long‐term kidney function. Ninety‐nine liver transplant patients receiving calcineurin inhibitor ( CNI )‐based immunosuppression, who had undergone a kidney biopsy at 60 ± 48 months post‐transplant, were included in this follow‐up study. Kidney biopsies were scored according to the B anff classification. Estimated glomerular filtration rate ( eGFR ) was assessed at last follow‐up, that is, 109 ± 48 months after liver transplantation. eGFR decreased from 92 ± 33 mL /min at transplantation to 63 ± 19 mL /min after six months, to 57 ± 17 mL /min at the kidney biopsy, to 54 ± 24 mL /min at last follow‐up (p < 0.0001). At last follow‐up, only three patients required renal replacement therapy. After the kidney biopsy, 13 patients were converted from CNI s to mammalian target of rapamycin inhibitors, but no significant improvement in eGFR was observed after conversion. Elevated eGFR at six months post‐transplant and a lower fibrous intimal thickening score (cv) observed at five yr post‐transplant were the two independent predictive factors for eGFR ≥60 mL/min at nine yr post‐transplant. Long‐term kidney function seems to be predicted by the kidney vascular lesions.