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Bone marrow findings of 23 K orean post‐transplant lymphoproliferative disorder patients: a single‐center experience
Author(s) -
Cho MinChul,
Park ChanJeoung,
Huh Jooryung,
Chi HyunSook,
Jang Seongsoo,
Suh Cheolwon,
Lee KyooHyung,
Lee JeHwan,
Seo Jong Jin,
Im Ho Joon
Publication year - 2012
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1111/j.1399-0012.2012.01667.x
Subject(s) - medicine , lymphoproliferative disorders , multiple myeloma , bone marrow , plasma cell myeloma , incidence (geometry) , lymphoma , pathology , single center , gastroenterology , biopsy , physics , optics
Background Work‐up of post‐transplant lymphoproliferative disorders ( PTLD s) often involves bone marrow ( BM ) examinations. We evaluated 23 transplant patients with PTLD s to investigate incidence of BM involvement and associated morphologic changes as well as prognosis. Methods We retrospectively assessed BM findings of 23 transplant patients with PTLD s who had undergone BM staging at S eoul A san M edical C enter from 1994 to 2010. Results Four (17%) showed BM involvement of PTLD s, including two pathologically diagnosed with PTLD by liver and skin biopsy and two diagnosed by BM examination. PTLD subtypes in four patients were all monomorphic, with one each having plasma cell myeloma, diffuse large B cell lymphoma, monomorphic B cell lineage, and monomorphic T ‐cell lineage. Epstein– B arr virus ( EBV ) in situ hybridization showed 11 of 23 (47.8%) patients were EBV positive, including two patients with BM involvement, one each with plasma cell myeloma and monomorphic T ‐cell lineage. Epstein–Barr virus infection was observed in nine of 19 patients (39.1%) without BM involvement or morphologic abnormalities. Mortality rate was higher in patients with than without BM involvement (p = 0.050). Conclusion High incidence of BM involvement in patients with PTLD and high mortality rates of these patients suggest BM examination study may be important in diagnosis and staging work‐up of PTLD .