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A case of BK virus nephropathy and cytomegalovirus infection concurrent with plasma cell–rich acute rejection
Author(s) -
Mafune Aki,
Tanno Yudo,
Yamamoto Hiroyasu,
Kobayashi Akimitsu,
Saigawa Hajime,
Yokoo Takashi,
Hayakawa Hiroshi,
Miyazaki Youichi,
Yokoyama Keitaro,
Yamaguchi Yutaka,
Hosoya Tatsuo
Publication year - 2012
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1111/j.1399-0012.2012.01646.x
Subject(s) - medicine , bk virus , cytomegalovirus infection , nephropathy , cytomegalovirus , immunology , virology , virus , herpesviridae , human cytomegalovirus , viral disease , endocrinology , diabetes mellitus
The BK virus is a double‐stranded DNA virus to which 90% of adults have been exposed. BK virus infections typically result in an oral or respiratory infection; however, BK virus reactivation is an infectious disease of concern in kidney transplant recipients. The prevalence of BK virus nephropathy ( BKN ) in kidney transplant recipients is approximately 5%, and most cases occur within one yr after kidney transplantation. Graft survival of BKN is reported to be 30–60%, and the standard treatment strategy for BKN is reducing immunosuppressive therapy and close monitoring for rejection. Viral infection is most common in the early post‐transplantation phase, and BKN or acute rejection is one of the major factors involved in graft loss. However, in this report, we describe the successful management of BKN and cytomegalovirus infection concurrent with plasma cell–rich acute rejection.