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A recurrent fibronectin glomerulopathy in a renal transplant patient: a case report
Author(s) -
Otsuka Yasuhiro,
Takeda Asami,
Horike Keiji,
Inaguma Daijyo,
Goto Norihiko,
Watarai Yoshihiko,
Uchida Kazuharu,
Mihatsch Michael J.,
Joh Kensuke,
Morozumi Kunio
Publication year - 2012
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1111/j.1399-0012.2012.01644.x
Subject(s) - medicine , transplantation , renal biopsy , glomerulopathy , pathology , mesangium , proteinuria , biopsy , end stage renal disease , glomerulonephritis , kidney , disease
Fibronectin glomerulopathy ( FNG ) is a rare, autosomal dominant renal disease with massive mesangial, and subendothelial fibronectin deposits. It presents proteinuria, often in the nephrotic range in the third to fourth decade, and slow progression to end‐stage renal disease. The risk of recurrent disease in renal allograft is uncertain. A Japanese female with end‐stage renal disease because of unknown origin received a renal transplant and was referred with proteinuria and mild deterioration of renal function four months after transplantation. Five allograft biopsies were underwent from one h to 12 months after the transplantation, including a biopsy 19 d after the transplantation, which revealed dense deposits suggesting fibronectin. A biopsy 134 d after the transplantation showed a feature of lobular glomerulonephritis corresponding FNG. The diagnosis was confirmed by IST4 positive and IST9 negative immunostaining together with typical fibrillary dense deposits in the mesangium and subendothelial spaces in electron microscopy. This is the first report of recurrent FNG in Japan.