Premium
Impact of vitamin D receptor gene polymorphisms on clinical outcomes of HLA‐matched sibling hematopoietic stem cell transplantation
Author(s) -
Cho Hyeon Jin,
Shin DongYeop,
Kim Jin Hee,
Bae JiYeon,
Lee KyungHun,
See Cha Ja,
Kim Naeyu,
Park Eun Kyung,
Ra Eun Kyung,
Lee JongEun,
Hong YunChul,
Kim Hyun Kyung,
Park Sung Sup,
Yoon SungSoo,
Lee Dong Soon,
Han KyouSup,
Park Myoung Hee,
Park Seonyang,
Kim Byoung Kook,
Kim Inho
Publication year - 2011
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1111/j.1399-0012.2011.01523.x
Subject(s) - taqi , haplotype , calcitriol receptor , foki , genotype , hematopoietic stem cell transplantation , transplantation , medicine , immunology , sibling , gastroenterology , biology , genetics , restriction fragment length polymorphism , polymorphism (computer science) , vitamin d and neurology , gene , psychology , developmental psychology
Cho HJ, Shin DY, Kim JH, Bae JY, Lee KH, See CJ, Kim N, Park EK, Ra EK, Lee JE, Hong YC, Kim HK, Park SS, Yoon SS, Lee DS, Han KS, Park MH, Park S, Kim BK, Kim I. Impact of vitamin D receptor gene polymorphisms on clinical outcomes of HLA‐matched sibling hematopoietic stem cell transplantation.
Clin Transplant 2011 DOI: 10.1111/j.1399‐0012.2011.01523.x.
© 2011 John Wiley & Sons A/S. Abstract: We hypothesized that polymorphisms of the vitamin D receptor (VDR) gene might affect clinical outcomes of allogeneic hematopoietic stem cell transplantation (HSCT). Three VDR gene polymorphisms ( Bsm I G>A, Apa I G>T, and Taq I T>C) were genotyped in 147 patients who underwent HLA‐matched sibling allogeneic HSCT. Frequencies of infection, graft‐vs.‐host disease (GVHD), overall survival (OS), and disease‐free survival (DFS) were compared according to genotypes and haplotypes. Infection and acute GVHD had trends to be less frequent in patients with Apa I TT genotype than non‐TT genotypes (p = 0.061 and p = 0.059, respectively). For Taq I genotypes, there were no statistical differences in frequency of infection and acute GVHD (p = 0.84 and p = 0.30, respectively), but TC genotype was associated with longer OS and DFS than TT genotype (p = 0.022 and p = 0.038, respectively). In the Apa I‐ Taq I haplotype analysis, patients with TC haplotype had significantly longer OS and DFS than those without TC haplotype (p = 0.022 and p = 0.038, respectively). In multivariable analysis, Taq I genotype and Apa I‐ Taq I haplotype of recipients were independent prognostic factors for both OS and DFS. This study suggests that the genotype and haplotype of VDR in recipient might be associated with clinical outcome of sibling HLA‐matched HSCT.