Premium
Impact of stable PGI 2 analog iloprost on early graft viability after liver transplantation: a pilot study
Author(s) -
Bärthel Erik,
Rauchfuß Falk,
Hoyer Heike,
Habrecht Olaf,
Jandt Karin,
Götz Max,
Voigt Rigo,
Heise Michael,
Marx Gernot,
Settmacher Utz
Publication year - 2011
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1111/j.1399-0012.2011.01516.x
Subject(s) - iloprost , medicine , transplantation , liver transplantation , microcirculation , reperfusion injury , ischemia , surgery , prostacyclin , urology , anesthesia
Bärthel E, Rauchfuß F, Hoyer H, Habrecht O, Jandt K, Götz M, Voigt R, Heise M, Marx G, Settmacher U. Impact of stable PGI 2 analog iloprost on early graft viability after liver transplantation: a pilot study.
Clin Transplant 2012: 26: E38–E47.
© 2011 John Wiley & Sons A/S. Abstract: Background: Ischemia/reperfusion injury after liver transplantation (LT) may be associated with primary graft dysfunction (PDF) or non‐function. Prostaglandins were demonstrated to be beneficial in reducing ischemic injury by improving microcirculation and protecting endothelial cells. The aim of this study was to analyze the effect of the continuously administered prostaglandin I 2 analog iloprost on allograft function after LT. Methods: Eighty patients were prospectively randomized and assigned to two groups. Patients in the treatment group received iloprost for seven d after transplantation, and those in the control group did not. The primary end point was graft dysfunction. Results: The incidence of PDF was 20% (n = 8) in the control group and 5% (n = 2) in the treatment group, respectively (p = 0.087). Four patients in the control group underwent re‐transplantation for initial non‐function (INF). There was no evidence for INF in the treatment group. Iloprost was associated with improved allograft function. Clinical course and outcome were comparable. Conclusions: We suggest iloprost to be beneficial for early post‐transplant liver function. If the rate of PDF can be significantly reduced with this treatment concept, it should be analyzed in a larger number of patients (ISRCTN95672167).