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Is adiponectin a marker of preclinical atherosclerosis in kidney transplantation?
Author(s) -
Cañas Laura,
Bayés Beatriz,
Granada Maria L.,
Iber Meritxell,
Porrini Esteban,
Benítez Rosa,
Díaz Juan M.,
Lauzurica Ricardo,
Moreso Francesc,
Torres Armando,
Lampreabe Ildefonso,
Serra Assumpta,
Romero Ramon
Publication year - 2011
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1111/j.1399-0012.2011.01490.x
Subject(s) - medicine , transplantation , adiponectin , kidney transplantation , intima media thickness , gastroenterology , endocrinology , diabetes mellitus , urology , insulin resistance , carotid arteries
Cañas L, Bayés B, Granada ML, Ibernon M, Porrini E, Benítez R, Díaz JM, Lauzurica R, Moreso F, Torres A, Lampreabe I, Serra A, Romero R. Is adiponectin a marker of preclinical atherosclerosis in kidney transplantation?
Clin Transplant 2011 DOI: 10.1111/j.1399‐0012.2011.01490.x.
© 2011 John Wiley & Sons A/S. Abstract: The aim of this study was to analyze the relationship between pre‐transplant adiponectin (pre‐ADP), abnormalities in glucose homeostasis (AGH) at three months post‐transplantation, and preclinical atherosclerosis in non‐diabetic patients prior to kidney transplantation (KT). Methods: We carried out a multicenter study in 157 non‐diabetic KT patients (66.5% men; age: 50 ± 13 yr). Pre‐ADP levels were analyzed using radioimmunoassay. Carotid ultrasound was performed to determine carotid intima‐media thickness (c‐IMT). Oral glucose tolerance test was carried out to classify patients according ADA criteria. Results: Of the patients, 52.8% had AGH. Median pre‐ADP was 19.5 (14–27) μg/mL. An inverse correlation was found between ADP and HOMA index ( r = −0.432; p < 0.001). Median c‐IMT was 0.6 (0.48–0.71) mm. Significant inverse correlation existed between ADP and c‐IMT on both sides (p < 0.05). Patients with c‐IMT >0.6 mm had more AGH (p = 0.012) and lower ADP levels (p = 0.02). We performed a logistic regression analysis using preclinical atherosclerosis (c‐IMT ≥0.6 mm) as dependent variable and sex, age, BMI, ADP, AGH, and HOMA index as independent variables of altered c‐IMT. Age, pre‐ADP, and AGH were independent risk factors for elevated c‐IMT. Conclusions: Patients with AGH have a greater presence of preclinical atherosclerosis. ADP has an inverse relationship with AGH and is an independent marker of preclinical atherosclerosis.