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Risk factors for post‐transplant lymphoproliferative disease in patients with cystic fibrosis
Author(s) -
Saueressig Maurício G.,
Boussaud Veronique,
Amrein Catherine,
Guillemain Romain,
Souilamas Jihane,
Souilamas Redha
Publication year - 2011
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1111/j.1399-0012.2011.01464.x
Subject(s) - medicine , serology , lung transplantation , gastroenterology , odds ratio , univariate analysis , lymphoproliferative disorders , transplantation , immunology , multivariate analysis , antibody , lymphoma
Saueressig MG, Boussaud V, Amrein C, Guillemain R, Souilamas J, Souilamas R. Risk factors for post‐transplant lymphoproliferative disease in patients with cystic fibrosis.
Clin Transplant 2011: 25: E430–E436. © 2011 John Wiley & Sons A/S. Abstract: The objective of this study was to retrospectively analyze risk factors associated with post‐transplant lymphoproliferative disease (PTLD) in a cohort of 112 lung transplant recipients with cystic fibrosis (CF). Prior to transplantation, patients were tested for Epstein–Barr virus (EBV), human herpesvirus (HHV types 1, 2, 3, 6, and 8), herpes zoster virus, and cytomegalovirus (CMV) serologies. PTLD diagnosis was established based on increased EBV viral charge plus clinical/radiographic findings and confirmed by biopsy. Negative EBV and HHV serologies at the time of lung transplantation (LTx) were significant risk factors associated with development of PTLD in patients with CF in the univariate logistic regression analysis (p < 0.05) and also in the multivariate analysis (odds ratio of 77.5 and 12.5, respectively). CMV serology, CMV mismatch, acute rejection in the first three months following LTx, HLA‐A3 antigen expression, and female gender did not affect PTLD. Our study confirmed the presence of a strong association between negative EBV serology at the time of LTx and PTLD and suggested an independent effect of negative HHV serology on PTLD.