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Graft volume as the surrogate marker for nephron number affects the outcomes of living‐donor kidney transplantation
Author(s) -
Han Seung Seok,
Yang Seung Hee,
Oh Yoon Jung,
Cho Jeong Yeon,
Moon Kyung Chul,
Ha Jongwon,
Kim Yon Su
Publication year - 2011
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1111/j.1399-0012.2011.01426.x
Subject(s) - medicine , urology , nephron , transplantation , kidney transplantation , kidney , biopsy , body surface area , surgery
Han SS, Yang SH, Oh YJ, Cho JY, Moon KC, Ha J, Kim YS. Graft volume as the surrogate marker for nephron number affects the outcomes of living‐donor kidney transplantation.
Clin Transplant 2011: 25: E327–E335. © 2011 John Wiley & Sons A/S. Abstract: Post‐transplant outcome of kidney allografts depends on various factors, one of which may be the compatibility in volume between graft and recipient. However, previous studies adjusted the graft volume only for recipient’s size. As the adjusted graft volume for donor’s size would be substituted of nephron number more accurately, we adjusted the graft volume for both recipient’s and donor’s sizes. In 351 cases of living‐donor kidney transplantation, we found that the adjusted graft volume for both recipient’s and donor’s body surface areas (BSAs) yielded larger area under the curves for the transplant outcomes than looking only at the adjusted volume for the recipient’s BSA. The recipients were separated into two groups according to the low and high adjusted graft volumes. During the follow‐up period (mean 55.6 months), the low‐graft‐volume group conferred greater risk of rejection, chronic change, glomerulonephritis, and graft loss than the high‐graft‐volume group (all p’s < 0.05). However, the frequency of T‐cell infiltration, as evaluated in protocol biopsy, was not different between the two adjusted graft volume groups. In conclusion, the graft volume as the surrogate marker for nephron number should be considered in kidney transplantation, especially in otherwise similar donor conditions.