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Growth of a nation part II: impact of recipient obesity on whole‐organ pancreas transplantation
Author(s) -
Fridell Jonathan A.,
Mangus Richard S.,
Taber Tim E.,
Goble Michelle L.,
Milgrom Martin L.,
Good Jason,
Vetor Ryan,
Powelson John A.
Publication year - 2011
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1111/j.1399-0012.2011.01422.x
Subject(s) - medicine , pancreas transplantation , overweight , incidence (geometry) , transplantation , pancreas , demographics , body mass index , obesity , kidney transplantation , weight loss , organ transplantation , gastroenterology , diabetes mellitus , surgery , endocrinology , demography , sociology , optics , physics
Fridell JA, Mangus RS, Taber TE, Goble ML, Milgrom ML, Good J, Vetor R, Powelson JA. Growth of a nation part II: impact of recipient obesity on whole‐organ pancreas transplantation.
Clin Transplant 2011: 25: E366–E374. © 2011 John Wiley & Sons A/S. Abstract: Obesity has reached epidemic proportions in the USA. Consequently, there is an increasing number of obese diabetic patients who would otherwise be appropriate candidates for pancreas transplantation (PTx). This is a retrospective study of all PTx performed at Indiana University between 2003 and 2009 (n = 308) comparing recipients with body mass index (BMI) < 25, 25–29.9, and ≥30 kg/m 2 Data included recipient and donor demographics, seven and 90‐d graft loss, one‐yr pancreas, kidney (for SPK only) and patient survival, causes of graft loss and death, peak amylase and lipase, length of stay, readmissions, complications, HbA1C, and c‐peptide. Of the 308 PTx, 100 (32%) were overweight and 42 (14%) were obese. Obese recipients were older and more likely to be men. Donor demographics were similar. There was no difference in seven‐d or 90‐d graft loss, one‐yr pancreas, kidney or patient survival, cause of graft loss or death, 30‐d peak amylase or lipase, HbA1C, or C‐peptide. The incidence of post‐transplant technical, immunological and infectious complications was similar except for an increased incidence of cytomegalovirus infection in the obese group. Two recipients returned to insulin therapy despite normal C‐peptide levels. Although technically challenging, PTx can be successful in select obese recipients with similar results compared to normal BMI recipients.