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Risk factors for development of new‐onset diabetes mellitus after transplant in adult lung transplant recipients
Author(s) -
Ye Xiaoyi,
Kuo HungTien,
Sampaio Marcelo Santos,
Jiang Yan,
Bunnapradist Suphamai
Publication year - 2010
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1111/j.1399-0012.2010.01383.x
Subject(s) - medicine , diabetes mellitus , lung , lung transplantation , risk factor , transplantation , intensive care medicine , endocrinology
Ye X, Kuo H‐T, Sampaio MS, Jiang Y, Bunnapradist S. Risk factors for development of new‐onset diabetes mellitus after transplant in adult lung transplant recipients.
Clin Transplant 2011: 25: 885–891. © 2010 John Wiley & Sons A/S. Abstract: The objectives of this study are to examine the incidence of new‐onset diabetes mellitus after transplant (NODAT) and to identify its risk factors in adult lung transplant recipients using the Organ Procurement and Transplant Network/United Network of Organ Sharing database. Between July 2004 and December 2007, a total of 3540 adults (≥18 yr old) received their first single‐ or double‐lung transplant alone and had at least one follow‐up report of post‐transplant diabetic status. Among these, 2991 recipients were identified as not having diabetes mellitus (DM) pre‐transplant. Risk factors for NODAT were examined. DM was newly reported in 33.4% of the 2991 recipients over the median follow‐up time of 670 d. Significant independent risk factors for the development of NODAT included male gender (HR = 1.15), recipient age ≥50 (1.46), African American (1.39), higher body mass index (1.51 for ≥30 vs. 18–25), cystic fibrosis (3.30), and tacrolimus use at discharge (1.67). NODAT occurred in a third of adult lung transplant recipients during the median follow‐up period. Some of the risk factors for NODAT after lung transplant are similar to those reported in other solid‐organ transplants. Cystic fibrosis is a strong risk factor for development of NODAT after lung transplant.