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WT1‐specific CTL cells of recipient origin may exist in the peripheral blood of patients achieving full donor chimerism soon after nonmyeloablative transplantation
Author(s) -
Wei Li,
Zuo Hongli,
Sun Xuedong,
Liu Tieqiang,
Guo Mei,
Liu Guangxian,
Sun Qiyun,
Qiao Jianhui,
Wang Danhong,
Yu Changlin,
Hu Kaixun,
Dong Zheng,
Ai Huisheng
Publication year - 2011
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1111/j.1399-0012.2010.01376.x
Subject(s) - medicine , peripheral blood , ctl* , immunology , transplantation , transplantation chimera , peripheral , immune system , hematopoietic cell , stem cell , surgery , genetics , haematopoiesis , biology , cd8
Wei L, Zuo H, Sun X, Liu T, Guo M, Liu G, Sun Q, Qiao J, Wang D, Yu C, Hu K, Dong Z, Ai H. WT1‐specific CTL cells of recipient origin may exist in the peripheral blood of patients achieving full donor chimerism soon after nonmyeloablative transplantation.
Clin Transplant 2011: 25: 689–696. © 2011 John Wiley & Sons A/S. Abstract: This study was performed to assay whether leukemia‐associated antigen (LAA)‐specific CTLs of recipient origin existed in the blood of patients who achieved full donor chimerism (FDC) soon after nonmyeloablative transplantation (NST). In 15 patients who received haplo‐identical NST, WT1 + CD8 + CTLs were detected with WT1/HLA‐A*0201 pentamer, and the donor–recipient chimerism levels were analyzed by three methods. Results showed that WT1 + CD8 + CTLs could be detected in patients with HLA‐A*0201 expressing only in recipient, and cells of recipient origin existed in the blood of patients who achieved FDC, which suggested that LAA‐specific CTLs of recipient origin may exist in patients achieving FDC soon after NST.