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Clostridium difficile ‐related pancolitis in lung‐transplanted patients with cystic fibrosis
Author(s) -
Patriarchi F.,
Rolla M.,
Maccioni F.,
Menichella A.,
Scacchi C.,
Ambrosini A.,
Costantino A.,
Quattrucci S.
Publication year - 2011
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1111/j.1399-0012.2010.01316.x
Subject(s) - medicine , cystic fibrosis , pancolitis , clostridium difficile colitis , clostridium difficile , immunosuppression , colitis , complication , gastroenterology , transplantation , asymptomatic , pseudomembranous colitis , lung , lung transplantation , antibiotics , colonoscopy , cancer , microbiology and biotechnology , colorectal cancer , biology
Patriarchi F, Rolla M, Maccioni F, Menichella A, Scacchi C, Ambrosini A, Costantino A, Quattrucci S. Clostridium difficile ‐related pancolitis in lung‐transplanted patients with cystic fibrosis.
Clin Transplant 2011: 25: E46–E51. © 2010 John Wiley & Sons A/S. Abstract: C. difficile (C. d.) is the main cause of antibiotic‐associated diarrhea and colitis. It is shown in literature a high asymptomatic carriage rate of C. d. in patients with cystic fibrosis (CF), though C. d.‐related colitis is an uncommon complication in these patients, despite the use of multiple high‐dose antibiotic regimes and the frequency of hospital admissions. Lung transplantation with the associated immunosuppression and aggressive antibiotic therapy may increase the risk of the clinical manifestation of C. d. In this paper, we describe three cases of severe C. d. colitis in patients with CF following lung transplantation and illustrate our experience in the diagnosis and management of these patients.