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Muco‐cutaneous manifestations in 178 renal transplant recipients
Author(s) -
Khosravi Masoud,
Golchai Javad,
Mokhtari Gholamreza
Publication year - 2010
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1111/j.1399-0012.2010.01284.x
Subject(s) - medicine , immunosuppression , basal cell carcinoma , dermatology , acne , biopsy , malignancy , lesion , skin biopsy , skin cancer , hypertrichosis , pathology , surgery , basal cell , cancer
Khosravi M, Golchai J, Mokhtari G. Muco‐cutaneous manifestations in 178 renal transplant recipients.
Clin Transplant 2011: 25: 395–400. © 2010 John Wiley & Sons A/S. Abstract: Introduction: Mucosal membrane and skin can be affected by immunosuppressive drug(s) and immunosuppression itself. The spectrum of muco‐cutaneous lesions can range from malignancy at one end to infection, iatrogenic lesions, and esthetic effects on the other end. Method: In Razi Hospital of Guilan University of Medical Sciences, a cross‐sectional study for the detection of muco‐cutaneous lesions in 178 renal transplant recipients (RTRs) was conducted from the years 2001 to 2006. Biopsy and skin scraping according to the type of skin lesions were performed. Results: A total of 31 RTRs (25%) had normal skin. Iatrogenic lesions were the most common (70%) followed by infectious lesions (57%), and miscellaneous skin lesions were exhibited by 26% of the patients. Among the iatrogenic skin lesions, gingival hyperplasia was the most common lesion (48%), followed by hypertrichosis and acne. Malignant lesions (biopsy proven) were recorded in seven patients (5%). Four patients were found to have Kaposi’s sarcoma, and three patients were identified with basal cell carcinoma. Conclusion: Our results showed that muco‐cutaneous lesions are crucial problems with RTRs. Attending physicians must pay close attention to skin care regularly and consider reduction of immunosuppression to a safe level, and patient must have self‐checkups.