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Induction of tolerance in clinical kidney transplantation
Author(s) -
Kawai Tatsuo,
Benedict Cosimi A.
Publication year - 2010
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1111/j.1399-0012.2010.01268.x
Subject(s) - medicine , transplantation , immune tolerance , kidney transplantation , kidney , immunology , blockade , transplantation chimera , surgery , immune system , stem cell , receptor , haematopoiesis , hematopoietic cell , microbiology and biotechnology , biology
Kawai T, Benedict Cosimi A. Induction of tolerance in clinical kidney transplantation.
Clin Transplant 2010: 24 (Suppl. 22): 2–5. © 2010 John Wiley & Sons A/S. Abstract: Induction of donor‐specific tolerance has been an ultimate goal in organ transplantation. Although numerous regimens for the induction of allograft tolerance have been developed in rodents, their application to primates has been limited. The approaches that have been successfully applied in primates can be divided into (i) use of total lymphoid irradiation, (ii) costimulatory blockade, (iii) profound depletion of recipient T cells, (iv) infusion of regulatory cells and (v) donor bone marrow (DBM) infusion/transplantation. Among these approaches, successful allograft tolerance has been achieved in clinical kidney transplantation using DBM transplantation.