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Hyperleptinemia positively correlated with metabolic syndrome in renal transplant recipients
Author(s) -
Lee MingChe,
Lee ChungJen,
Ho GuanJin,
Lee ChiaChi,
Shih MingHui,
Chou KueiChun,
Hsu BangGee
Publication year - 2010
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1111/j.1399-0012.2010.01215.x
Subject(s) - medicine , metabolic syndrome , waist , endocrinology , body mass index , leptin , diabetes mellitus , renal transplant , obesity , stepwise regression , univariate analysis , gastroenterology , transplantation , multivariate analysis
Lee M‐C, Lee C‐J, Ho G‐J, Lee C‐C, Shih M‐H, Chou K‐C, Hsu B‐G. Hyperleptinemia positively correlated with metabolic syndrome in renal transplant recipients.
Clin Transplant 2010: 24: E124–E129.
© 2010 John Wiley & Sons A/S. Abstract: Objective: Our aim was to evaluate the relationship between metabolic syndrome and fasting serum leptin concentration in renal transplant recipients. Patients and methods: Fasting blood samples were obtained from 55 renal transplant recipients. Metabolic syndrome and its components were defined using the diagnostic criteria of the International Diabetes Federation. Results: Thirteen patients (23.6%) had metabolic syndrome. Fasting leptin concentrations were positively correlated with metabolic syndrome (p = 0.003). Univariate linear regression analysis indicated fasting serum leptin values were positively correlated with waist circumference ( r = 0.284; p = 0.036), body mass index ( r = 0.358; p = 0.007), body fat mass ( r = 0.610; p < 0.001), triglycerides ( r = 0.268; p = 0.048), high‐sensitivity C‐reactive protein (hs‐CRP) ( r = 0.377; p = 0.005), triceps skinfold ( r = 0.335; p = 0.012), and mid‐arm fat area ( r = 0.351; p = 0.009). Multivariate forward stepwise linear regression analysis of the significant variables revealed that body fat mass ( R 2 change = 0.373; p < 0.001) and hs‐CRP ( R 2 change = 0.045; p = 0.049) were the independent predictors of fasting serum leptin concentration. Conclusion: Serum leptin concentration correlates positively with metabolic syndrome in renal transplant recipients.