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Synchronous hepatic, mesenteric and pulmonary Epstein–Barr virus‐associated smooth muscle tumors in a renal transplant recipient
Author(s) -
Al Hussain T.,
Haleem A,
Alsaad K. O.
Publication year - 2010
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1111/j.1399-0012.2009.01206.x
Subject(s) - medicine , renal transplant , epstein–barr virus , pathology , kidney , virus , immunology
Al Hussain T, Haleem A, Alsaad KO. Synchronous hepatic, mesenteric and pulmonary Epstein–Barr virus‐associated smooth muscle tumors in a renal transplant recipient.
Clin Transplant 2010. DOI: 10.1111/j.1399‐0012.2009.01206.x
© 2010 John Wiley & Sons A/S. Abstract: Epstein–Barr virus‐associated smooth muscle tumors (EBV‐SMT) are distinct lesions that occur in immunocompromised patients. EBV‐SMT following solid organ transplantation are rare and generally have an indolent biological behavior. Post‐transplant EBV‐SMT have been reported in various anatomical locations. This report describes a synchronous and multicentric development of EBV‐SMT in liver, mesentery, and lung of a 33‐yr‐old male patient, 10 yr after a deceased allograft renal transplantation. The hepatic and mesenteric tumors were available for study. These tumors were composed of bland looking, desmin‐positive, spindle‐shaped cells which showed a strong nuclear staining for EBV with in situ hybridization technique. A literature review of post solid organ transplant EBV‐SMT in the liver and lung, particularly regarding their pathogenesis, synchronicity and biological behavior would be provided.