Premium
The association between eNOS intron 4 VNTR polymorphism and delayed graft function of kidney allografts
Author(s) -
Dutkiewicz Grażyna,
Domanski Leszek,
BinczakKuleta Agnieszka,
Pawlik Andrzej,
Safranow Krzysztof,
Ciechanowicz Andrzej,
Dziedziejko Violetta,
Ciechanowski Kazimierz
Publication year - 2009
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1111/j.1399-0012.2009.01187.x
Subject(s) - enos , intron , medicine , allele , exon , transplantation , kidney , nitric oxide , immunology , gene , genetics , biology , nitric oxide synthase
Dutkiewicz G, Domanski L, Binczak‐Kuleta A, Pawlik A, Safranow K, Ciechanowicz A, Dziedziejko V, Ciechanowski K. The association between eNOS intron 4 VNTR polymorphism and delayed graft function of kidney allografts.
Clin Transplant 2009 DOI: 10.1111/j.1399‐0012.2009.01187.x
© 2009 John Wiley & Sons A/S. Abstract: Nitric oxide (NO) is a multifunctional agent which serves as a key signaling molecule in physiological processes such as host defense, neuronal communication, and the regulation of vascular tone. Different polymorphic variations have been identified in the human NOS3 ( eNOS ) gene.The aim of the present study was to examine the association between polymorphisms of the NOS3 gene (G894T substitution within exon 7 and intron 4 VNTR polymorphism) and the development of delayed graft function as well as acute and chronic rejection.One hundred eighty‐seven recipients of first renal transplants were included in the study. There were no significant associations between these polymorphisms and acute and chronic kidney allograft rejection. The intron 4 polymorphism was associated with delayed graft function after transplantation. The results of this study suggest that patients with the a allele of the eNOS intron 4 VNTR polymorphism may be predisposed to delayed graft function.