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Association of plasma pentosidine concentrations with renal function in kidney graft recipients
Author(s) -
SlowikZylka Dorota,
Safranow Krzysztof,
Dziedziejko Violetta,
Ciechanowski Kazimierz,
Chlubek Dariusz
Publication year - 2010
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1111/j.1399-0012.2009.01176.x
Subject(s) - medicine , pentosidine , renal function , kidney , urology , kidney disease , endocrinology , diabetes mellitus , glycation
Slowik‐Zylka D, Safranow K, Dziedziejko V, Ciechanowski K, Chlubek D. Association of plasma pentosidine concentrations with renal function in kidney graft recipients.
Clin Transplant 2010: 24: 839–847. © 2009 John Wiley & Sons A/S. Abstract: Background: Advanced glycation end‐products accumulate in the plasma of uremic patients. We aimed to assess the changes of free ( P free ) and total ( P tot ) plasma pentosidine concentrations in kidney graft recipients, create a model describing their profile and analyze associations with clinical parameters. Material and methods: We measured P free and P tot in the plasma of 12 non‐diabetic patients before and after kidney transplantation by HPLC. Results: Ptot concentrations were significantly decreasing after transplantation. The changes were well described by the exponential model assuming an asymptotic fall until the steady‐state concentration is attained. P tot before and after transplantation displayed a strong negative correlation with mean daily diuresis ( R s = −0.64, p < 0.05 before; R s = −0.94, p < 0.01 after 20 d). The rate of fall of the P tot was positively correlated with the mean daily volume of urine passed in the second week after operation ( R s = +0.58, p < 0.05). Conclusions: The rate of fall of the P tot after transplantation displays a strong correlation with diuresis, and the P tot before transplantation is a potential prognostic factor for diuresis after the operation. Further prospective studies are necessary to demonstrate whether an effort to reduce carbonyl stress and pentosidine concentration before transplantation improves renal outcome.