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Antibody‐mediated rejection of renal allograft in combined liver–kidney transplant
Author(s) -
Barth Rolf N.,
Campos Luis,
Kukuruga Debra L.,
Drachenberg Cinthia,
Philosophe Benjamin
Publication year - 2009
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1111/j.1399-0012.2009.01161.x
Subject(s) - medicine , liver transplantation , kidney , transplantation , abo blood group system , kidney transplantation , urology , antibody , renal function , pathology , gastroenterology , immunology
Barth RN, Campos L, Kukuruga DL, Drachenberg C, Philosophe B. Antibody‐mediated rejection of renal allograft in combined liver–kidney transplant.
Clin Transplant 2009 DOI: 10.1111/j.1399‐0012.2009.01161.x
© 2009 John Wiley & Sons A/S. Abstract: Liver transplantation is performed based on ABO blood type compatibility without dependence on crossmatch results. Combined liver–kidney transplantation (CLKT) is similarly performed without dependence of crossmatch results as the liver is thought to confer protection to the renal allograft against alloantibody. We report a case of CLKT in a sensitized patient with antibody‐mediated rejection (AMR) of the renal allograft. AMR was confirmed with C4d staining and serial monitoring of donor‐specific antibody (DSA). Despite intensive therapy directed against AMR and the presence of the liver allograft, the patient demonstrated increasing titers of alloantibody, never demonstrated adequate renal function, and ultimately expired after two months. This result demonstrates the potential for AMR of the renal allograft in sensitized recipients of CLKT.