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Chronic allograft nephropathy – a clinical syndrome: early detection and the potential role of proliferation signal inhibitors
Author(s) -
Campistol Josep M.,
Boletis Ioannis N.,
Dantal Jacques,
De Fijter Johan W.,
Hertig Alexandre,
Neumayer Hans H.,
Øyen Ole,
Pascual Julio,
Pohanka Erich,
Ruiz Juan C.,
Scolari Maria P.,
Stefoni Sergio,
Serón Daniel,
Sparacino Vito,
Arns Wolfgang,
Chapman Jeremy R.
Publication year - 2009
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1111/j.1399-0012.2009.01057.x
Subject(s) - medicine , calcineurin , sirolimus , chronic allograft nephropathy , everolimus , transplantation , nephropathy , clinical trial , kidney transplantation , intensive care medicine , endocrinology , diabetes mellitus
Chronic allograft nephropathy (CAN) leads to the majority of late graft loss following renal transplantation. Detection of CAN is often too late to permit early intervention and successful management. Most current strategies for managing CAN rely on minimizing or eliminating calcineurin inhibitors (CNIs) once CAN has become established. The proliferation signal inhibitors everolimus and sirolimus have potent immunosuppressive and antiproliferative actions, with the potential to alter the natural history of CAN by reducing CNI exposure whilst avoiding acute rejection. Whilst data will be forthcoming from a number of clinical trials investigating this potential, we discuss early detection of CAN and the rationale for a role for this class of agent.