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The impact of functioning pancreas–kidney transplantation and pancreas alone transplantation on the lipid metabolism of statin‐naïve diabetic patients
Author(s) -
Lauria Márcio W,
Figueiró José Maria,
Machado Lucas José Campos,
Sanches Marcelo D.,
Lana Ângela Maria Quintão,
RibeiroOliveira Jr Antônio
Publication year - 2009
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1111/j.1399-0012.2009.00969.x
Subject(s) - medicine , transplantation , immunosuppression , pancreas transplantation , diabetes mellitus , endocrinology , kidney transplantation , tacrolimus , cholesterol , triglyceride , gastroenterology
Objective: To compare the lipid profile (total cholesterol – TC, triglycerides – TG, high density lipoprotein cholesterol – HDL‐c, low density lipoprotein cholesterol – LDL‐c and non‐HDL cholesterol – NHDL‐c) of patients with functioning pancreas–kidney transplantation (PKT) or pancreas transplantation alone (PTA) after one (T1) and two yr (T2) following their pre‐transplantation data (T0). Methods: Fifty‐three type 1 diabetic patients underwent pancreas transplantation (42 PKT and 11 PTA) remaining euglycemic after transplantation were evaluated before and one and two yr after the procedures. They were using predominantly tacrolimus‐mycophenolate mofetil‐based immunosuppression and low glucocorticoid dose with systemic venous drainage of the pancreatic graft. None of them used hypolipidemic agents for economical reasons. Lipids were reported as means ± standard error of the mean. Data obtained in T0 were compared with T1 and T2 using ANOVA followed by Student’s t ‐test. Results: TC, LDL‐c, NHDL‐c and TG were lower in T1 and T2 when compared with T0 (p < 0.05) in PKT, while no change was observed for HDL‐c (p > 0.05). PTA group showed no significant changes in lipids. Conclusion: In spite of the known side effects of tacrolimus‐based immunosuppression to lipids, our study with a statin‐naïve sample showed improvements (PKT) or stabilization (PTA) in the serum lipid profile after pancreas transplantation.