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Myeloma kidney with isolated tubulointerstitial light chain deposition in a renal allograft
Author(s) -
Balamuthusamy S.,
Hamrahian M.,
Zhang R.,
Batuman V.
Publication year - 2009
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1111/j.1399-0012.2009.00967.x
Subject(s) - medicine , kidney , multiple myeloma , immunoglobulin light chain , nephropathy , kidney disease , proteinuria , pathology , biopsy , kidney transplantation , renal biopsy , renal function , immunology , endocrinology , diabetes mellitus , antibody
Myeloma kidney and myeloma‐associated renal disorders including light chain deposition disease can occur as recurrent or de novo disease in renal allografts. These kidney disorders usually manifest with worsening allograft function and proteinuria. Identification of the precise cause of kidney disorder often requires kidney biopsy and demonstration of monoclonal light chains in the kidney. Here, we present an unusual case of light chain nephropathy in a living‐related kidney transplant recipient involving light chain crystallization in the proximal tubule occurring within less than three months after transplant. The etiology of renal failure prior to transplant in our patient is not clear. To the best of our knowledge, the ultrastructural changes seen in our patient have not been described in literature previously. Our patient was treated with steroids, which resulted in short‐term improvement in allograft dysfunction.