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Administration of donor‐derived transplant acceptance‐inducing cells to the recipients of renal transplants from deceased donors is technically feasible
Author(s) -
Hutchinson James A.,
Gövert Felix,
Riquelme Paloma,
Bräsen Jan Hinrich,
BremExner Beate G.,
Matthäi Martina,
Schulze Maren,
Renders Lutz,
Kunzendorf Ulrich,
Geissler Edward K.,
Fändrich Fred
Publication year - 2009
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1111/j.1399-0012.2008.00953.x
Subject(s) - medicine , tacrolimus , renal transplant , transplantation , complication , surgery , kidney transplantation , immunosuppression , kidney , urology
Patient KW, a 36‐yr‐old male renal transplant recipient, received transplant acceptance‐inducing cells (TAICs) as an adjunct immunosuppressive therapy. In the weeks post‐transplantation, the patient’s conventional immunosuppressive treatment was gradually minimized, such that, from the 21st wk post‐transplantation onwards, the patient was stably maintained on tacrolimus monotherapy. Treatment with TAICs was without complication, both at the time of administration and in the four‐yr follow‐up period. It is concluded that the production and administration of TAICs to recipients of kidney transplants from deceased donors is technically feasible.