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Normalization of endothelial dysfunction following renal transplantation is accompanied by a reduction of circulating visfatin/NAMPT. A novel marker of endothelial damage?
Author(s) -
Yilmaz Mahmut Ilker,
Saglam Mutlu,
Carrero Juan Jesus,
Qureshi Abdul R.,
Caglar Kayser,
Eyileten Tayfun,
Sonmez Alper,
Oguz Yusuf,
Aslan Ismail,
Vural Abdulgaffar,
Yenicesu Mujdat,
Stenvinkel Peter,
Lindholm Bengt,
Axelsson Jonas
Publication year - 2009
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1111/j.1399-0012.2008.00921.x
Subject(s) - medicine , adiponectin , transplantation , endothelial dysfunction , endocrinology , kidney transplantation , diabetes mellitus , brachial artery , kidney disease , tacrolimus , renal function , insulin resistance , blood pressure
Endothelial dysfunction is strongly linked to cardiovascular disease and outcome of patients with chronic kidney disease. We hypothesized that decreased inflammatory activity and increased adiponectin following transplantation could be one mechanism for a better endothelial health. Fifty‐eight living donor kidney transplant non‐diabetic recipients, 31 (23 male, 29 ± 5 yr) on cyclosporine A and 27 (10 male, 26 ± 5 yr) on tacrolimus immunsupression, were studied longitudinally. Visfatin, adiponectin, high sensitive C‐reactive protein (hsCRP) levels, brachial artery flow mediated dilatation (FMD) and nitroglycerine mediated dilatation were measured before transplantation and on the 30th and 90th day after transplantation. Pre‐transplantation visfatin, adiponectin and FMD values of patients were significantly higher than those of the controls (p < 0.001 for all). All values decreased significantly 30 and 90 d post‐transplantation. Plasma visfatin and adiponectin, correlated negatively with FMD levels 90 d both before and after kidney transplantation (p < 0.001 for both). Endothelial function improved during the first month after transplantation, and the degree of improvement correlated to reductions in circulating visfatin, adiponectin and hsCRP levels. Of interest, the intracellular enzyme visfatin was the strongest predictor of FMD both before and after kidney transplantation and may thus reflect endothelial cell damage directly.