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Model for the end‐stage liver disease and death prediction in a cohort of Brazilian patients on the waiting list for liver transplantation
Author(s) -
Brandão Ajacio,
Fuchs Sandra C,
Gleisner Ana L,
Marroni Claudio,
Zanotelli Maria L,
Cantisani Guido
Publication year - 2008
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1111/j.1399-0012.2008.00860.x
Subject(s) - medicine , liver transplantation , model for end stage liver disease , receiver operating characteristic , liver disease , cohort , hazard ratio , proportional hazards model , transplantation , stage (stratigraphy) , survival analysis , surgery , confidence interval , paleontology , biology
Background/aim: To examine the performance of the model for end‐stage liver disease (MELD) score to predict mortality three and six months after enlistment of patients with chronic diseases for their first liver transplantation (LT) and to compare the performances of the Child–Turcotte–Pugh (CTP) and the Erasmus Model for End‐stage Resistant‐to‐therapy All etiology Liver Disease (EMERALD) scores with the MELD to predict mortality. Methods: Cohort study. Receiver operating characteristics curve (ROC) curves were used to determine the ability of the scores for predicting three and six month mortality, the c ‐statistic to establish the predictive power of each score and the Cox proportional hazard model to estimate the risk of dying. Results: We studied 271 patients. At enlistment, the mean MELD and EMERALD scores were 14.8 and 26.6, respectively. Approximately 61% of the cases were in the CTP B category. During the three or six month follow‐up period, the percentage of patients dying, receiving LT or remaining on the list were 11.8%, 9.2%, and 79.0% or 19.2%, 17.7%, and 63.1%, respectively. The three‐month mortality was similarly predicted by the scores MELD, EMERALD and CTP ( c ‐statistic of 0.79, 0.74, and 0.70, respectively). Six‐month mortality presented similar AUC and ROC curves. Conclusion: The scores predicted mortality for the three or six months, but the performance of the MELD was better than CTP and EMERALD scores.