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Practical tests for clinical diagnosis of kidney allograft dysfunction
Author(s) -
Miura Masayoshi,
Harada Hiroshi,
Morooka Kanako,
Tanabe Tatsu,
Takada Norikata,
Seki Toshimori,
Togashi Masaki,
Hirano Tetsuo
Publication year - 2008
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1111/j.1399-0012.2008.00840.x
Subject(s) - medicine , perioperative , transplantation , organ dysfunction , toxicity , kidney transplantation , drug toxicity , biopsy , surgery , intensive care medicine , sepsis
Abstract: Graft dysfunction after renal transplant occurs due to a variety of causes. Graft biopsy is a mainstay in the diagnosis of graft dysfunction, including rejection, infection, glomerulonephritis and drug toxicity. Clinical tests including regular laboratory tests, antibody tests and imaging studies, however, are also important in the process of diagnosis. The possible causes of graft dysfunction are different depending on the period after transplantation. Pre‐transplant donor factors may also affect the early graft function. Perioperative graft dysfunction is mainly related to hemodynamic factors and surgical complications. Early acute rejection may occur in immunologically high‐risk cases. Later graft dysfunction may be related to infection, acute and chronic rejection or drug toxicity. Clinical tests to differentiate these factors are discussed in this paper.