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A case of acute vascular rejection after overseas deceased kidney transplantation
Author(s) -
Shimizu Tomokazu,
Ishida Hideki,
Kobayashi Hiroshi,
Tanabe Kazunari,
Masumoto Kentaro,
Tsunoyama Kuniko,
Iizuka Junpei,
Tokumoto Tadahiko,
Kajimoto Shun’ichi,
Yamaguchi Yutaka
Publication year - 2007
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1111/j.1399-0012.2007.00718.x
Subject(s) - medicine , prednisone , immunosuppression , transplantation , creatinine , kidney transplantation , kidney , surgery , biopsy , urology , gastroenterology
A 54‐yr‐old Japanese male received overseas deceased kidney transplantation in January 2006. His allograft functioned immediately and he received immunosuppression with cyclosporine A (CyA), mycophenolate mofetil (MMF), and prednisone (PR). On day 24 after transplantation, he came back to Japan. His serum creatinine level (s‐Cr) was 1.39 mg/dL at two months after transplantation when he was admitted into Toda Central General Hospital on March 2006, for follow‐up his renal allograft. He had taken only two immunosuppressive drugs, MMF and PR, and had not taken CyA at that time. His serum creatinine gradually rose after hospitalization. Allograft biopsy performed on April 6, 2006, showed acute vascular rejection (Banff 97 acute/active cellular rejection Grade III), together with suspicious for acute humoral rejection (Banff 97 antibody‐mediated rejection Grade II). After treatment of two courses of steroid pulses and five d of gusperimus, acute vascular rejection and acute humoral rejection were relieved, which had been proven by the third allograft biopsy. In conclusion, this was a case of acute vascular rejection after overseas deceased kidney transplantation, resulted from non‐compliance with immunosuppressive therapy.