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Invasive zygomycosis in transplant recipients
Author(s) -
Uçkay Ilker,
Chalandon Yves,
Sartoretti Pascal,
Rohner Peter,
Berney Thierry,
Hadaya Karine,
Van Delden Christian
Publication year - 2007
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1111/j.1399-0012.2007.00684.x
Subject(s) - zygomycosis , medicine , amphotericin b , mucormycosis , bone marrow transplant , opportunistic infection , antifungal , surgery , organ transplantation , mycosis , transplantation , dermatology , bone marrow transplantation , immunology , human immunodeficiency virus (hiv) , viral disease
Zygomycosis are rare fungal infections occurring mainly in immunocompromised patients. To date only 160 cases have been published in transplant recipients. We report four new cases of zygomycosis in transplant recipients illustrating the large clinical spectrum of this infection: one disseminated infection with heart involvement and one rhinocerebral infection with dissemination in two bone marrow transplant recipients, one cutaneous infection in a liver and one pulmonary infection in a kidney recipient. All cases, except the cutaneous infection that was accessible to surgical resection and a systemic antifungal treatment, were fatal. In transplant recipients cumulating risk factors for zygomycosis, a high index of suspicion is required. Early diagnosis and combining surgery with systemic amphotericin‐B are mandatory to improve survival rates.