Premium
Graft‐vs.‐host disease in lung and other solid organ transplant recipients
Author(s) -
Assi Maha A,
Pulido Jose S,
Peters Steve G,
McCannel Colin A,
Razonable Raymund R
Publication year - 2007
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1111/j.1399-0012.2006.00573.x
Subject(s) - medicine , rash , complication , cytopenia , organ transplantation , disease , transplantation , lung , lung transplantation , diarrhea , graft versus host disease , solid organ , surgery , bone marrow
Graft‐vs.‐host disease (GVHD) is an uncommon complication of solid organ transplantation. Herein, we report a case of GVHD occurring in a lung transplant recipient and review 29 reported cases of GVHD that complicated thoracic organ, and non‐hepatic intra‐abdominal organ transplantation. The major presenting clinical symptom of GVHD was skin rash. Less frequent clinical manifestations were cytopenia (16%), diarrhea (11%), and fever (5%). The mainstay of treatment was high‐dose corticosteroids. The mortality rate was high (30%). The cause of death was mainly due to infection, suggesting that antimicrobial prophylaxis may improve the outcome of this potentially fatal complication.