Premium
Changes of clotting factors (7, 9 and 10) and hepatocyte growth factor in patients with thrombotic microangiopathy after bone marrow transplantation
Author(s) -
Takatsuka Hiroyuki,
Nakajima Toshiyuki,
Nomura Kaori,
Okikawa Yoshiko,
Wakae Takeshi,
Toda Akinari,
Itoi Hisayuki,
Okada Masaya,
Misawa Mahito,
Hara Hiroshi,
Ogawa Hiroyasu
Publication year - 2006
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1111/j.1399-0012.2006.00530.x
Subject(s) - thrombotic microangiopathy , medicine , hepatocyte growth factor , clotting factor , bone marrow transplantation , gastroenterology , microangiopathy , bone marrow , transplantation , risk factor , endocrinology , receptor , disease , diabetes mellitus
To investigate risk factors for thrombotic microangiopathy (TMA) after bone marrow transplantation (BMT), the levels of three clotting factors (7, 9 and 10) and hepatocyte growth factor (HGF) were measured. Among 46 consecutive patients who underwent BMT, six developed TMA and 40 did not. The levels of the clotting factors and HGF did not differ significantly between the six patients with TMA and the 40 patients without it. In two patients who developed TMA during the earlyperiod after BMT, however, the levels of the three clotting factors were significantly decreased even before BMT, along with a significant increase of HGF. These findings suggest that patients with severe hepatic dysfunction before BMT, especially those with impaired protein synthesis, had an increased risk of developing TMA soon after BMT. It was also suggested that measurement of clotting factors (7, 9 and 10) and HGF may be useful to predict the occurrence of TMA in the early period after BMT.