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Incidence and prevalence of diabetes mellitus in patients with cystic fibrosis undergoing lung transplantation before and after lung transplantation *
Author(s) -
Hadjiliadis Denis,
Madill Janet,
Chaparro Cecilia,
Tsang Anna,
Waddell Thomas K,
Singer Lianne G,
Hutcheon Michael A,
Keshavjee Shaf,
Elizabeth Tullis D
Publication year - 2005
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1111/j.1399-0012.2005.00420.x
Subject(s) - medicine , cystic fibrosis , transplantation , diabetes mellitus , lung transplantation , interquartile range , lung , population , gastroenterology , incidence (geometry) , pancreatic disease , surgery , pancreas , endocrinology , physics , environmental health , optics
Cystic fibrosis (CF) related diabetes mellitus (DM) occurs in 15% of adult pancreatic insufficient CF patients. Lung transplantation is a treatment option for end‐stage CF. We hypothesized that the prevalence of DM increases after lung transplantation. The study population included adult patients undergoing lung transplantation from March 1988 to March 2002 for end‐stage CF at the University of Toronto. Demographic data, exocrine pancreatic function, presence of DM before and after transplant, as well as timing of its development after transplant were collected. Eighty‐six patients met the study criteria; 77 of 86 (89.5%) of patients were pancreatic insufficient and were further analyzed. Median follow‐up post‐transplant was 3.3 yr (interquartile range: 1.2–7.2). Their mean age was 29.7 ± 8.1 yr and 46 of 77 (59.7%) were male. The prevalence of DM increased from 22 of 77 (28.6%) before transplant to 38 of 77 (49.4%) after transplant (p = 0.008). The median time of DM development after transplant was 80 d (range: 13–4352). Sixteen of 55 (29.1%) of pancreatic insufficient patients who were non‐diabetic prior to transplant, developed DM after transplant. DM is common in CF patients undergoing lung transplantation and the prevalence increases after transplant.