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Living and deceased donor liver transplantation for unresectable hepatoblastoma at a single center
Author(s) -
Mejia Alejandro,
Langnas Alan N,
Shaw Byers W,
Torres Clarivet,
Sudan Debra L
Publication year - 2005
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1111/j.1399-0012.2005.00410.x
Subject(s) - hepatoblastoma , medicine , single center , liver transplantation , transplantation , living donor liver transplantation , center (category theory) , oncology , surgery , chemistry , crystallography
Hepatoblastoma (HB) is the most common malignant liver tumor in children. The application of living donor liver transplantation (LDLT) in the management of unresectable HB may add new therapeutic opportunities. We evaluated the outcomes of patients who underwent liver transplantation for treatment of unresectable HB in the period between August 1985 and June 2003. Ten children had a diagnosis of unresectable HB. Mean age at transplantation was 5.8 yr. Eight patients were transplanted with deceased donor grafts. Two patients underwent LDLT. Pre‐transplant chemotherapy was used in 90% of cases. Post‐transplant survival ranges from 3.7 to 18.6 yr. Three patients died of recurrent disease at 4, 14 and 38 months. The two LDLT recipients were able to get pre‐transplant chemotherapy with a rapid decision towards transplantation; both are alive and well at 5.5 and 11 yr post‐transplant. Our experience supports the role of LDLT and deceased donor liver transplantation in the management of unresectable HB when waiting times can be detrimental to the patient's survival.